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Any future retatrutide prescribing guidance would define its own stopping criteria in its Summary of Product Characteristics (SmPC) and any relevant NICE technology appraisal, if licensed

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These medications work by mimicking the effects of a hormone called GLP-1, which is naturally produced by the intestine in response to food intake

However, the inhibition of -GCS activity by GSH is of physiological significance [7] and is the rate-limiting step in GSH biosynthesis